Investigating CFTR and KCa3.1 Protein/Protein Interactions
نویسندگان
چکیده
منابع مشابه
Investigating CFTR and KCa3.1 Protein/Protein Interactions
In epithelia, Cl- channels play a prominent role in fluid and electrolyte transport. Of particular importance is the cAMP-dependent cystic fibrosis transmembrane conductance regulator Cl- channel (CFTR) with mutations of the CFTR encoding gene causing cystic fibrosis. The bulk transepithelial transport of Cl- ions and electrolytes needs however to be coupled to an increase in K+ conductance in ...
متن کاملMining Gene-Disease Relationships from Biomedical Literature: Weighting Proteinprotein Interactions and Connectivity
Motivation: The promises of the post-genome era disease-related discoveries and advances have yet to be fully realized, with many opportunities for discovery hiding in the millions of biomedical papers published since. Public databases give access to data extracted from the literature by teams of experts, but their coverage is often limited and lags behind recent discoveries. We present a compu...
متن کاملStructural models of CFTR–AMPK and CFTR–PKA interactions: R-domain flexibility is a key factor in CFTR regulation
Cystic fibrosis (CF), the most common lethal genetic disease among Caucasians, is caused by mutations in cystic fibrosis transmembrane conductance regulator (CFTR). CFTR's main role is to transport chloride ions across epithelial cell membranes. It also regulates many cell functions. However, the exact role of CFTR in cellular processes is not yet fully understood. It is recognized that a key f...
متن کاملInvestigating interactions of trust and interest similarity
Online communities that allow their users to express their personal preferences, such as the members they trust and the products they appreciate, are becoming increasingly popular. Exploiting these communities as playgrounds for sociological research we present two frameworks for analyzing the correlation between interpersonal trust and interest similarity. We obtain empirical results from appl...
متن کاملA Novel, Comprehensive Method to Detect and Predict Proteinprotein Interactions Applied to the Study of Vesicular Trafficking
Motivation. Computational methods to predict protein–protein interactions are of great need. They can help to formulate hypotheses, guide experimental research and serve as additional measures to assess the quality of data obtained in high-throughput interaction experiments. Here, we describe a fully automated threestep procedure to predict and confirm protein–protein interactions. By maximisin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLOS ONE
سال: 2016
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0153665